[This dataset is embargoed until December 31, 2026]. This dataset includes a range of determinants present in sediments and water at 8 locations along the Thane River, Vashi Creek, Mumbai between October 2021 and November 2023. Variables measured include geochemical parameters pH, Ec, OM, MC, LOI, TOC, potentially toxic elements; Al, As, Al, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, Sn, Se, V, Zn, and anions; fluoride, nitrite, bromide, nitrate, phosphate, and sulphate. Data also includes antibiotic quantification within the Creek over the same time point. Data includes quantity of Azithromycin, Ciprofloxacin, Enrofloxacin, Erythromycin, Levofloxacin, Linezolid, Oxacillin, Penicillin, and Sulfamethazine. Full details about this dataset can be found at https://doi.org/10.5285/b22b914c-e2fc-4298-879a-1bd24f242b3c